The reference site for Trazodone

Trazodone (sold under many brand names worldwide) is an antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class. It is a phenylpiperazine compound.

WHAT IS Trazodone?

Trazodone is an antidepressant medication. It works by changing the actions of chemicals in the brain.

Trazodone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.

As well as those mentioned above, some other trazodone brand names include Trittico® and Thombran®.


Brand Name(s): Desyrel; Trazon; Trialodine
CAS nº: 19794-93-5
(trah zoe done)


Product Info

The sections below will provide you with more specific information and guidelines related to trazodone and its correct use. Please read them carefully.

FDA Information

Trazodone was approved by the U.S. FDA in 1982.

The FDA recently advised that trazodone be used with caution in patients receiving amprenavir. If this drug combination is used, a lower dose of trazodone should be considered. Concomitant use of trazodone and amprenavir (with or without ritonavir) may result in increased trazodone plasma concentrations and adverse events, such as nausea, dizziness, hypotension, and syncope.

Why is this medication prescribed?

Trazodone is an antidepressant medication. It works by changing the actions of chemicals in the brain.

Trazodone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.

Other uses for this medicine

Trazodone is also sometimes used to treat schizophrenia (long lasting, disabling mental illness in which the patient loses touch with reality); anxiety (excessive worry); alcohol abuse; and abnormal, uncontrollable movements that may be experienced as side effects of other medications.

Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Trazodone comes as a tablet, and is to be taken by mouth.

Treatment should be started with low initial doses of 75 to 150 mg daily in divided doses or in an evening single dose. The dose may be increased slowly to a maximum of 300mg daily in ambulatory patients and to 600 mg daily in hospitalized patients. Geriatric and emaciated patients should begin with 100 mg daily, but may be slowly increased to 300 mg.

The dose of trazodone will be different for each patient. Follow your doctor’s orders or the directions on the label.

It is usually taken with a meal or light snack two or more times a day. To help you remember to take trazodone, take it around the same times every day.

Trazodone controls depression, but does not cure it. It may take 2 weeks or longer before you feel the full benefit of trazodone.

Continue to take trazodone even if you feel well. Do not stop taking trazodone without talking to your doctor. Your doctor will probably decrease your dose gradually.

What special precautions should I follow?


Tell your doctor and pharmacist if you are allergic to trazodone or any other medications.

Inform your doctor and pharmacist what other prescription and non-prescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: anticoagulants (‘blood thinners’) such as warfarin (Coumadin); antidepressants, especially selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delaviridine (Rescriptor); dexamethasone (Decadron); digoxin (Digitek, Lanoxin, Lanoxicaps); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); isoniazid (INH, Nydrazid); medications for allergies, cough or colds; medications for anxiety, high blood pressure, irregular heartbeat, mental illness or pain; medication for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metronidazole (Flagyl); muscle relaxants; nefazodone; oral contraceptives (birth control pills); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; sleeping pills; tranquilizers; troleandomycin (TAO); verapamil (Calan, Isoptin, Verelan); or zafirlukast (Accolate).

Also, tell your doctor or pharmacist if you are taking the following medications, called MAO inhibitors, or if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Carbex), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what herbal products you are taking, especially St. John’s wort.

Tell your doctor if you or anyone in your family has or has ever had depression, bipolar disorder (mood that changes from depressed to abnormally excited), or mania (frenzied, abnormally excited mood), or if you or anyone in your family has thought about or attempted suicide.

Also, inform your doctor if you are being treated with electroshock therapy and if you have or have ever had cancer, a heart attack, irregular heart beat, high blood pressure, human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDs), low white blood cell count, or heart disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.

You should know that trazodone may make you drowsy and affect your judgment. Do not drive a car or operate machinery until you know how this medication affects you. If drowsiness is a problem, ask your doctor about taking part of your dose at bedtime.

Ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.

NOTE – You should know that your mental health may change in unexpected ways, especially at the beginning of your treatment and any time that your dose is increased or decreased. These changes may occur at any time if you have depression or another mental illness, whether or not you are taking trazodone or any other medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied, abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

You should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Studies have shown that children and teenagers who take antidepressants such as trazodone may be more likely to think about harming or killing themselves or to plan or try to do so.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Common side effects that you could experience from using trazodone:

upset stomach
stomach pain or gas
weakness or tiredness
excitement or anxiety
dry mouth
skin more sensitive to sunlight than usual
changes in appetite or weight

Tell your doctor if any of these symptoms are severe or do not go away:

difficulty urinating
frequent urination
blurred vision
changes in sex drive or ability
excessive sweating

If you experience any of the following symptoms, call your doctor immediately:

jaw, neck, and back muscle spasms
slow or difficult speech
shuffling walk
persistent fine tremor or inability to sit still
dizziness or lightheadedness
blood in urine
difficulty breathing
shortness of breath
severe skin rash
yellowing of the skin or eyes
irregular heartbeat
prolonged or inappropriate erection

Trazodone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

an irregular heart beat
difficulty breathing
painful erection

Product Images


Below you will find images and specific information on the principal types of trazodone that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 100 MG
Imprint: DESYREL MJ 776
Manufacturer: APOTHECON

Strength(s): 150 MG
Imprint: 50|50|50 MJ 778
Manufacturer: PD-RX PHARM.

Strength(s): 50 MG
Imprint: barr 555 489
Manufacturer: BARR LABS.

Strength(s): 50 MG
Imprint: GG 419
Manufacturer: GENEVA

Strength(s): 50 MG
Imprint: PLIVA 433
Manufacturer: PLIVA, INC.

Strength(s): 50 MG
Imprint: 439 R
Manufacturer: PUREPAC PHARM.

Strength(s): 100 MG
Imprint: 555 490 barr
Manufacturer: BARR LABS.

Strength(s): 100 MG
Imprint: GG 420
Manufacturer: GENEVA

Strength(s): 100 MG
Imprint: 5599 DAN
Manufacturer: SCHEIN

Strength(s): 150 MG
Imprint: barr 732 50|50|50
Manufacturer: BARR LABS.

Strength(s): 150 MG
Imprint: MP 168 25|25|50|50
Manufacturer: MUTUAL PHARM CO.

Strength(s): 150 MG
Imprint: SL 441 50|50|50
Manufacturer: PLIVA, INC.

Strength(s): 150 MG
Imprint: AP 3171 50|50|50
Manufacturer: SANDOZ

Strength(s): 300 MG
Imprint: barr 733 100|100|100
Manufacturer: BARR LABS

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